Probenecid- Water Soluble
Probenecid is used to inhibit organic-anion transporters located in the cell membrane. These transporters can extrude dyes and indicators and can contribute to poor loading or a high background signal in assays based on retention of the dyes or indicators inside cells. The free acid form of probenecid requires 1 M NaOH to dissolve into solution, TEFLabs water soluble probenecid dissolves quickly in assay buffer and eliminates the need to handle caustic NaOH. The water-soluble probenecid is included in several TEFLabs assay kits including, Fluo-2 NW Calcium Assay Kits, and is also available separately.