Calcium Ionophores

The calcium ionophore A-23187 and its brominated derivative, 4-Bromo-A-23187, are used to facilitate transport of extracellular Ca2+ into cells. These ionophores also facilitate transport of some other divalent cations, such as manganese (Mn2+).


A-23187 has an intrinsic fluorescence excitable by UV light, making it less useful with UV-excitable Ca2+ indicators, e.g., Fura-2,but it is still useful for long-wavelength Ca2+ indicators, e.g., Fluo-2.

4-Bromo-A-23187 is nonfluorescent and is thus compatible with all Ca2+ indicators.

 

Related Products

SQI-Pr

SQI-Et

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Asante Calcium Red

Fura-2